Endothelium-in DMEK in complex eyes | Webinar recap

Dive into a comprehensive exploration of this evolving technique, breaking down its mechanics, challenges and potential advantages over traditional methods

Endothelium-in DMEK in complex eyes | Webinar recap

By Michael Szkarlat, Partner Development Director
Disclaimer: Medical information is not medical advice—read our disclaimer.
The February 2025 Eversight Academy webinar set the stage for an exciting year of discussions on advancements in corneal care. Dr. Christopher Sales, associate professor of ophthalmology at the University of Iowa Department of Ophthalmology and Visual Sciences, led an in-depth session on Endothelium-in Descemet Membrane Endothelial Keratoplasty (DMEK) and its application in complex eyes. Known for his expertise in minimally invasive corneal transplantation, Dr. Sales provided a comprehensive exploration of this evolving technique, breaking down its mechanics, challenges and potential advantages over traditional methods. 

The evolution of DMEK: Understanding the shift

DMEK has grown in popularity over the past decade, particularly for treating Fuchs dystrophy. While conventional DMEK techniques, such as endothelium-out methods, have been widely used, Dr. Sales focused on a newer approach—Endothelium-in pull-through DMEK. This method, he explained, leverages the natural recoil forces of the corneal tissue to facilitate graft unfolding, rather than relying on frictional forces and external manipulation. 

Endothelium-in DMEK: A complex yet promising approach

The webinar delved into the intricacies of Endothelium-in DMEK, with Dr. Sales sharing surgical videos demonstrating how the tissue, when pulled through, naturally unfurls within the anterior chamber. He contrasted this with the conventional Endothelium-out, tap-technique DMEK, where surgeons manually tap the cornea to unfold the graft. 

While the technique shows promise, it is not without challenges. Dr. Sales described the procedure as “ergonomically complex” due to the intricate hand positioning and coordination required. He emphasized that mastering Endothelium-out DMEK is essential before incorporating Endothelium-in DMEK into surgical practice. 

Case selection and surgical considerations

Dr. Sales outlined the types of cases best suited for Endothelium-in DMEK, including post-vitrectomy eyes, anterior chamber intraocular lenses (ACIOLs), and eyes with nearly opaque corneas. He also highlighted situations where Endothelium-out DMEK remains the preferred choice, such as cases involving non-vitrectomized eyes with normal anterior chamber depth. 

The discussion also touched on tissue handling, with Dr. Sales recommending a collaborative approach with eye banks to ensure proper graft preparation.  

Looking ahead: Efficiency and outcomes

One of the key takeaways from the webinar was the efficacy of DMEK compared to Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Dr. Sales cited studies suggesting that while DMEK may initially pose a learning curve, it offers long-term benefits such as faster visual recovery, reduced interface fluid complications and better endothelial cell survival. 

Stay tuned for more insights

Eversight Academy’s webinar series continues in May with a session featuring Dr. Sophie Deng from the UCLA Jules Stein Eye Institute, discussing the management of limbal stem cell deficiency. Stay connected for more educational opportunities as we explore the latest advancements in corneal care. 

Missed the webinar? Keep an eye on your inbox for future sessions and join us as we continue advancing the gift of sight through innovation and collaboration. 



Eversight's free webinars are a great way for you to connect, learn and train digitally with leading ophthalmologists and researchers from around the world. We invite you to RSVP for scheduled webinars and browse our recording library.

Have an idea for a future topic? Interested in receiving timely and relevant information from Eversight? We'd love to hear from you!


Share this Post

About the author

Michael Szkarlat, Partner Development Director

Michael has been with Eversight since 2016 and has recently worked to develop Eversight's educational wet lab programs for EK surgery and a standardized protocol for DALK practice in a wet lab setting. His eye banking experience is rooted in the preparation of corneal grafts and spent nearly five years as Eversight’s Medical Director designee in charge of training clinical team members to prepare corneal tissue for DMEK and DSAEK surgery. In his time at Eversight, Michael has presented at scientific conferences, been involved in clinical research and developed innovations in tissue processing. He was named an IAPB Eye Heath Hero in the innovations category. Michael is passionate about community-based eye banking and honoring the precious gift that is donation. When not at work, he enjoys traveling with his wife and baking artisan sourdough bread.


In this season of gratitude, Eversight has launched a matching

#GivingTuesday

campaign to impact even more lives. Please consider supporting Eversight and help us earn a generous $4,000 match from our Board of Directors.
GIVE TODAY
close-link

Stay in touch

Help us tailor your Eversight experience by subscribing to information that is meaningful to you.
Subscribe now
close-link